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  1. 1779
    Future Hawaiian king meets British explorer
    Kamehameha, the 25-year-old future monarch of Hawai‘i and nephew of King Kalani‘opu‘u of the Big Island ...
  2. 1780
    Smallpox epidemics strike Mexico and the Great Plains
    For two years, smallpox spreads from Mexico north and throughout the Great Plains, killing many members ...
  3. 1802
    Army vaccinates Indians in Ohio to protect soldiers
    U.S. Army physicians vaccinate a small number of Indians in Ohio, the new frontier, against smallpox ...
  4. 1802
    An estimated 150,000 dead at Ne-cha-co-lee, a Chinook city
    The expedition led by Meriwether Lewis and William Clark arrives at a Chinook village in Oregon that ...
  5. 1804
    Epidemic strikes Kamehameha’s warriors on O‘ahu
    As King Kamehameha prepares to attack the island of Kaua‘i from his base on O‘ahu to expand his influence ...
  6. 1823
    Leprosy is suspected in Hawai‘i
    Native Hawaiians report that a mysterious disease has arrived in their islands from China, brought by ...
  7. 1824–26
    Pulmonary epidemic hits Hawai‘i
    An epidemic that is suspected to be whooping cough kills thousands of Native Hawaiians. ... Whooping cough, ...
  8. 1824
    Kamehameha II dies at 27 of measles
    King Kamehameha II and Queen Kamamalu of Hawai‘i sail to London to seek an audience with King George ...
  9. 1826
    Mosquitoes arrive in Hawai‘i
    European and American ships carry the first mosquitoes to Hawai‘i, where there are no blood-sucking ...
  10. 1828
    Medical missionary arrives in Hawai‘i
    Dr. Gerritt P. Judd, a medical missionary, arrives in the Hawaiian Islands, intending to treat Native ...
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