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  1. 1831
    Ka‘ahumanu orders Catholic missionaries out of Hawai‘i
    Queen Ka‘ahumanu forces Catholic missionaries to leave or be imprisoned. Ka‘ahumanu, who has fought ...
  2. 1836
    Hawaiian monarchs order foreigners screened for smallpox
    Kuhina Nui Elizabeth Kaho‘anoku Kina‘u (a wife of the late Kamehameha II) takes the first documented ...
  3. 1838
    First Hawaiian-language medical text is published
    Dr. Gerrit P. Judd publishes Anatomica , a book about human anatomy written in the Hawaiian language. ...
  4. 1839
    Kamehameha III makes quarantine laws
    King Kamehameha III establishes quarantine laws and the first records of vital statistics in the Hawaiian ...
  5. 1840
    Hawaiian Constitution established
    Kamehameha III, along with the Council of Chiefs and a group of Western advisors, establishes Hawai‘ ...
  6. 1841
    Native Hawaiian workers mistreated on sugar plantations
    Anglo-American businessmen begin to shift the native agricultural economy to a plantation system of ...
  7. 1843
    Hawai‘i’s independence recognized
    Great Britain and France sign a reciprocal agreement in which both nations formally recognize the independence ...
  8. 1845–48
    A series of epidemics kills thousands in Hawai‘i
    Successive epidemics of diarrhea, influenza, measles, and whooping cough kill 10,000 in the Hawaiian ...
  9. 1847
    Pharmacies open in Hawai‘i
    In Honolulu, Dr. G. Watson and Dr. Robert Wood found three pharmacies—the first in Hawai‘i. ... Medicine ...
  10. 1848
    Successive epidemics spread across U.S., Alaska, Hawai‘i
    In September, a series of deadly epidemics, including measles, whooping cough, and influenza, sweeps ...
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