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  1. AD 1493
    Spanish settlers enslave the Taíno of Hispaniola
    Spain founds Santo Domingo, the first of many towns on the Caribbean island Hispaniola (now the location ...
  2. AD 1493
    The Pope asserts rights to colonize, convert, and enslave
    Pope Alexander VI issues a papal bull or decree, “Inter Caetera," in which he authorizes Spain and Portugal ...
  3. AD 1493
    Cattle carry influenza to the Taíno
    On a second voyage to the Caribbean island Hispaniola, the fleet of Christopher Columbus carries domestic ...
  4. AD 1513
    El Requierimento: Spain demands subservience
    The “Laws of Burgos” are the first legal code regarding Spanish actions in the Americas. They direct ...
  5. AD 1518
    Mayans report smallpox spread to Yucatan Peninsula
    Mayan writings record that tribal trade expeditions traveling by canoe have spread smallpox to the Yucatan ...
  6. AD 1537
    Pope Paul III opposes enslaving Native peoples
    Pope Paul III issues a decree, “Sublimus Deus,” opposing the enslavement of indigenous peoples and calling ...