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  1. 1780
    Smallpox epidemics strike Mexico and the Great Plains
    For two years, smallpox spreads from Mexico north and throughout the Great Plains, killing many members ...
  2. 1802
    An estimated 150,000 dead at Ne-cha-co-lee, a Chinook city
    The expedition led by Meriwether Lewis and William Clark arrives at a Chinook village in Oregon that ...
  3. 1829–33
    Northwest tribes tell of smallpox arrival
    Oral histories describe sailors from a ship from Chile handing out gifts to make peace and encourage ...