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  1. AD 1492
    Taíno meet Columbus; “New World” gets new diseases
    In the Bahamas, the Taíno are 125,000 strong in 1492 when they encounter the crew and the Italian captain ...
  2. AD 1493–1550s
    Native peoples begin dying from European diseases
    Diseases unknown to them spread rapidly among Native peoples, who lack immunity to viruses and bacteria ...
  3. AD 1493
    Cattle carry influenza to the Taíno
    On a second voyage to the Caribbean island Hispaniola, the fleet of Christopher Columbus carries domestic ...
  4. AD 1520–62
    ‘Virgin-soil’ epidemics devastate Native populations
    “Virgin-soil” epidemics sweep through populations with no prior exposure to a particular infectious ...
  5. AD 1560
    A conquistador finds Coosa villages abandoned
    Tristán de Luna is ordered to establish a Spanish settlement on the Gulf Coast and an overland trade ...
  6. AD 1564
    Epidemic decimates Timuacan in Florida
    Once 50,000 strong, the Timuacan living between the barrier islands of what is now Georgia and the area ...
  7. AD 1566
    The Calusa battle Spain over conversion
    The Calusa Indians, who live in southwest Florida, are weakened by epidemics. They are attacked by Spain, ...
  8. AD 1585
    English scouts infect Lumbee on Roanoke Island
    Sir Walter Raleigh sponsors colonists who try establish the first English settlement in Virginia. An ...
  9. AD 1607
    British colonists settle in Powhatan territory
    More than 30 tribes and an estimated 20,000 Indians, including Mattaponi, Pamunkey, and Chickahominy ...
  10. AD 1659
    Measles decimates Native peoples of Florida
    In Florida, 10,000 Timuacans, Apalachee, Pensacola, Tocobaga, Calusa, Tequesta, Jeaga, Jobe, and Ais ...
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