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  1. AD 1492
    Taíno meet Columbus; “New World” gets new diseases
    In the Bahamas, the Taíno are 125,000 strong in 1492 when they encounter the crew and the Italian captain ...
  2. AD 1493–1550s
    Native peoples begin dying from European diseases
    Diseases unknown to them spread rapidly among Native peoples, who lack immunity to viruses and bacteria ...
  3. AD 1493
    Cattle carry influenza to the Taíno
    On a second voyage to the Caribbean island Hispaniola, the fleet of Christopher Columbus carries domestic ...
  4. AD 1503
    Foreigners come for cod; carry disease to New England
    For generations, teeming schools of codfish support Native peoples along the North Atlantic coast. After ...
  5. AD 1506–18
    Viruses move inland along with French traders
    The Haudenosaunee (Iroquois) and Huron begin exchanging goods with French traders pushing inland from ...
  6. AD 1518
    Mayans report smallpox spread to Yucatan Peninsula
    Mayan writings record that tribal trade expeditions traveling by canoe have spread smallpox to the Yucatan ...
  7. AD 1520–62
    ‘Virgin-soil’ epidemics devastate Native populations
    “Virgin-soil” epidemics sweep through populations with no prior exposure to a particular infectious ...
  8. AD 1531–33
    Mesoamericans succumb to deadly measles epidemic
    Maya, Toltec, Quechua, and many other peoples in Mesoamerica die in great numbers from measles wherever ...
  9. AD 1560
    A conquistador finds Coosa villages abandoned
    Tristán de Luna is ordered to establish a Spanish settlement on the Gulf Coast and an overland trade ...
  10. AD 1564
    Epidemic decimates Timuacan in Florida
    Once 50,000 strong, the Timuacan living between the barrier islands of what is now Georgia and the area ...
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