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  1. 1779
    Future Hawaiian king meets British explorer
    Kamehameha, the 25-year-old future monarch of Hawai‘i and nephew of King Kalani‘opu‘u of the Big Island ...
  2. 1804
    Epidemic strikes Kamehameha’s warriors on O‘ahu
    As King Kamehameha prepares to attack the island of Kaua‘i from his base on O‘ahu to expand his influence ...
  3. 1823
    Leprosy is suspected in Hawai‘i
    Native Hawaiians report that a mysterious disease has arrived in their islands from China, brought by ...
  4. 1824–26
    Pulmonary epidemic hits Hawai‘i
    An epidemic that is suspected to be whooping cough kills thousands of Native Hawaiians. ... Whooping cough, ...
  5. 1824
    Kamehameha II dies at 27 of measles
    King Kamehameha II and Queen Kamamalu of Hawai‘i sail to London to seek an audience with King George ...
  6. 1826
    Mosquitoes arrive in Hawai‘i
    European and American ships carry the first mosquitoes to Hawai‘i, where there are no blood-sucking ...
  7. 1828
    Medical missionary arrives in Hawai‘i
    Dr. Gerritt P. Judd, a medical missionary, arrives in the Hawaiian Islands, intending to treat Native ...
  8. 1836
    Hawaiian monarchs order foreigners screened for smallpox
    Kuhina Nui Elizabeth Kaho‘anoku Kina‘u (a wife of the late Kamehameha II) takes the first documented ...
  9. 1839
    Kamehameha III makes quarantine laws
    King Kamehameha III establishes quarantine laws and the first records of vital statistics in the Hawaiian ...
  10. 1845–48
    A series of epidemics kills thousands in Hawai‘i
    Successive epidemics of diarrhea, influenza, measles, and whooping cough kill 10,000 in the Hawaiian ...
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