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  1. 1776
    American colonies accuse Britain of inciting Native insurrections
    Enumerating the colonies’ grievances against Britain, the Declaration of Independence charges that King ...
  2. 1776
    Oneida and Tuscarora back George Washington
    In the American Revolutionary War, the Oneida and Tuscarora tribes side with General George Washington. ...
  3. 1775
    Smallpox strikes again in North America
    As the American Revolution begins, epidemic smallpox spreads across North America, killing hundreds ...
  4. 1768
    Britain stops protecting American colonies from Native attack
    As American settlements continue to encroach on Native lands, the colonies express worry about attacks ...
  5. 1763
    Treaty of Paris ends war; Britain claims Native lands
    England and France end the Seven Years’ War (1756–63, also called the French and Indian War). In the ...
  6. 1763
    Indian Proclamation Line ignored; settlers move west
    After the Seven Years’ War, the British Parliament creates the Indian Proclamation Line of 1763, which ...
  7. 1763–64
    Britain wages biological warfare with smallpox
    The British give smallpox-contaminated blankets to Shawnee and Lenape (Delaware) communities—an action ...
  8. 1761
    First known influenza pandemic from the Americas begins
    Influenza is one of the diseases that Europeans brought to the New World. Unlike previous influenza ...
  9. 1755–56
    Smallpox sweeps through northern British colonies
    Epidemics of smallpox and measles strike in Massachusetts, Rhode Island, Connecticut, New York, and ...
  10. 1721
    Inoculations save some from smallpox
    During a smallpox epidemic in Boston, Dr. Zabdiel Boylston inoculates (purposefuly infects) his son and ...
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