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  1. 1776
    American colonies accuse Britain of inciting Native insurrections
    Enumerating the colonies’ grievances against Britain, the Declaration of Independence charges that King ...
  2. 1776
    Oneida and Tuscarora back George Washington
    In the American Revolutionary War, the Oneida and Tuscarora tribes side with General George Washington. ...
  3. 1775
    Smallpox strikes again in North America
    As the American Revolution begins, epidemic smallpox spreads across North America, killing hundreds ...
  4. 1768
    Britain stops protecting American colonies from Native attack
    As American settlements continue to encroach on Native lands, the colonies express worry about attacks ...
  5. 1763
    Treaty of Paris ends war; Britain claims Native lands
    England and France end the Seven Years’ War (1756–63, also called the French and Indian War). In the ...
  6. 1763
    Indian Proclamation Line ignored; settlers move west
    After the Seven Years’ War, the British Parliament creates the Indian Proclamation Line of 1763, which ...
  7. 1761
    First known influenza pandemic from the Americas begins
    Influenza is one of the diseases that Europeans brought to the New World. Unlike previous influenza ...
  8. 1700
    Virginia Native peoples succumb to smallpox
    Between 1600 and 1700, 75 percent of the Native peoples in Virginia die, including members of the once ...
  9. AD 1659
    Measles decimates Native peoples of Florida
    In Florida, 10,000 Timuacans, Apalachee, Pensacola, Tocobaga, Calusa, Tequesta, Jeaga, Jobe, and Ais ...
  10. AD 1644
    England declares war on the Powhatan Chiefdom
    Virginia, now a colony of the English crown, commits royal troops to defeat the Powhatan Chiefdom. The ...
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